The Serrekunda-based outfit are struggling second place from bottom with only 9 points in thirteen league matches, and will be hunting to blow Brikama United and move from the danger zone after losing to the Brikama-based outfit 1-0 in the first round.
The Brikama-based outfit are among the teams contending for the league with 20 points in thirteen league matches.
They will be playing all out to beat Serrekunda United and mount pressure on league leaders Gambia Ports Authority.
Bombada will play against Steve Biko at the Father Gough Sports Complex in Manjai Kunda.
The Brikama-based outfit are one place above relegation zone with 10 points in thirteen league matches and need to beat Steve Biko to improve their position in the league and also bounce back in the league after losing to Real De Banjul 1-0 at the weekend.
The Bakau giant killers are now among the teams fighting for the league title with 18 points in thirteen league matches nine points behind league leaders. They will be inspiring to knock Bombada to mount pressure on league leaders Gambia Ports Authority.
Real De Banjul will take on defending league champions Gamtel at the Banjul KG5 Mini Stadium.
The city boys and telecommunication giants are among the teams striving for the league title. They and will be coming all out to beat each of their opponents to increase their hopes of winning the league title.
Real De Banjul are fourth place in the league with 19 points in thirteen league matches, and Gamtel are second spot in the league with 21 points in thirteen league matches.
Elsewhere, Hawks will rub shoulders with Gambia Ports Authority at the Serrekunda West Mini Stadium on the same day.
The red devils are mid-table in the top flight with 16 points in thirteen league matches, and will be hut to beat Gambia Ports Authority to end their thirteen match unbeaten run in the league.
The ferry boys are currently leading the league table with 27 points in thirteen league matches, and will be challenging to defeat Hawks to renew their lead in the summit.