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Drug-resistant tuberculosis in W/Africa higher than expected

Nov 21, 2016, 11:35 AM | Article By: Abdoulie Nyockeh

The prevalence of multidrug-resistant tuberculosis (MDR-TB) is unexpectedly high in eight West African countries, research by the West African Network of Excellence for TB, AIDS and Malaria (WANETAM) has revealed.

According to the research published in the open access journal, BMC Medicine, MDR-TB could become a serious public health threat in West Africa unless effective surveillance and control measures are implemented.

In a press release from Medical Research Council Gambia office (MRCG), Professor Martin Antonio, principal investigator at MRCG, who led WANETAM’s TB-related activities, said: “To our surprise, we found that multidrug-resistant and pre-extensively drug-resistant tuberculosis strains are already widely circulating, and that drug resistance is a much bigger problem in West Africa than previously anticipated.

“WHO estimates the prevalence of multidrug resistance in new and retreatment cases to be 2% and 17% respectively, but we found that it is 6% and 35% respectively.

“We recommend that efforts be put in place for containment of a potential West African TB epidemic at the earliest possible stage.  This is especially important, as West Africa with its 245 million inhabitants, is one of the poorest regions globally, whose fragile health systems can easily be overwhelmed by infectious disease epidemics, as seen in the recent Ebola outbreak.

“Analysis of 974 bacterial samples collected from patients with TB revealed that 39% were resistant to at least one first-line drug and 22% were multidrug-resistant.  Pre-extensively drug-resistant TB isolates were found to be present at all study sites, with Ghana showing the highest proportion, where 35% of MDR samples were pre-extensively drug-resistant.

“Multidrug-resistant bacteria are resistant to two or more of the first-line drugs used for the treatment of a disease.  Pre-extensively drug-resistant bacteria are on the verge of developing into extensively drug-resistant bacteria, which are resistant to the second-line drugs that are used if first-line treatment fails.

“MDR-TB prevalence was highest among patients previously treated for TB in Bamako, Mali (59%) and in Ibadan (39%) and Lagos (66%), Nigeria.  Bacteria isolated from these retreatment patients were four times more likely to be resistant to one or more first-line drugs when compared to bacteria isolated from new patients.

“Due to poor laboratory infrastructure and inadequate capacity, at the start of WANETAM, data on drug-resistant TB prevalence in West Africa were scarce so prevalence was assumed to be comparably low and not considered a major public health problem. Our data shows that this may not be the case.

“In order to take steps to remedy the lack of laboratory infrastructure and to generate comprehensive data on drug resistance prevalence in West Africa, WANETAM trained local laboratory staff to perform routine diagnostics such as standardised smear microscopy and mycobacterial culture.”

Dr Florian Gehre, a postdoctoral researcher and first author of the paper said: “In Lagos, 32% of new TB patients tested positive for the MDR-TB strains. Even when considering a potential sampling bias in the study, it is uncommon for new patients to acquire MDR-TB, except if patients with MDR-TB strains transmit these strains directly to new patients or new patients infect each other.”

Professor Souleymane Mboup, head of the Bacteriology Virology Department at the University Hospital Le Dantec, University of Dakar, Senegal, and the overall principal investigator for the WANETAM project said: “This is the first time that leading scientists and research institutes in West Africa joined forces to create a research network that provides research opportunities, fosters collaborations, builds capacity and trains members in basic and advanced laboratory techniques to independently conduct TB drug resistance surveys.

“The infrastructure built by WANETAM will help countries in West Africa to respond effectively to emerging public health threats and to conduct trials to address local health needs and inform health policies.”

Professor Umberto D’Alessandro, MRC Gambia Unit director, said: “Besides building infrastructures and training local research teams, WANETAM has been able to produce highly relevant and high quality information for the control of TB in West Africa.

“I hope WANETAM will continue to provide a major contribution to the fight against diseases of public health importance in Africa.”

WANETAM, founded in 2008, comprises nine study sites in Burkina Faso, The Gambia, Ghana, Guinea-Bissau, Mali, Nigeria, Senegal and Togo.

The WANETAM study was the first to achieve a comprehensive overview of drug resistance in the sub-region.

The researchers said although more data is needed to fully assess the risk of a drug-resistant TB epidemic in West Africa, the results from this study should prompt the implementation of continuous surveillance of all retreatment patients in participating countries.