Brikama United are second spot in the top flight, four points behind league leader Gambia Ports Authority with 37 points in twenty league matches.
They will therefore search for a win against Bombada to close gap on league leaders.
Bombada are two places above relegation zone with 20 points in twenty league matches and want to avenge to bounce back after losing to Brikama United 2-1 in the first round, to improve their position in the league.